[ref. f62161922] Scientist I/Scientist II (Chemical Biology), EDDC - Toa Payoh

About EDDC

We collaborate with both public sector and industry partners to translate scientific discoveries in Singapore’s biomedical and clinical research into innovative healthcare solutions.

Position Summary

The successful candidate will be developing chemical biology approaches to uncover disease molecular mechanisms, identify new therapeutic targets, and create innovative therapeutics modalities. As part of a dynamic and collaborative team, you will drive projects towards important milestones, conduct independent research, and collaborate across disciplines to advance novel therapeutic strategies.

• Lead and manage research projects, ensuring timely delivery of milestones and high-quality outcomes.
• Collaborate cross-functionally with medicinal chemists, biochemists, molecular biologists, structural biologists and computational scientists, to drive ongoing research and development projects in a fast-paced environment.
• Develop chemical biology approaches aimed at confirming target engagement of small molecules with protein of interest both in vitro and in cellular systems.
• Experience in the design and synthesis of chemical probes would be a plus.
• Stay up to date with advancements in chemical biology and drug discovery.
• Oversee the upkeep of lab equipment and ensure adherence to good housekeeping practices in the lab.
• Maintain detailed, accurate laboratory records and ensure compliance with safety regulations.

• A PhD in Chemical Biology is preferred. Applicants with a PhD in Biology, Chemistry, or related disciplines with relevant skill sets may also apply.
• Candidates with background in immunology would be advantageous.

• Biology lab skills: Strong expertise in wet lab research eg. mammalian cell culture, cellular assays (Western Blotting, co-immunoprecipitation, TURBO-ID), cell-based fluorescence imaging, molecular biology (CRISPR knockout screen) and bioanalytical techniques (ligand binding assays).
• Chemistry lab skills: Expertise in the design, synthesis, purification and characterisation of chemical compounds or chemical probes would be advantageous.
• Chemical Biology lab skills: Experience with Activity-Based Protein Profiling (ABPP), Affinity-Based Protein Profiling (AfBP), and chemoproteomics is a plus.
• Strong passion for interdisciplinary research and exploring novel therapeutic approaches.
• Self-motivated, fast learner with strong organization skills.
• Able to excel in a fast-paced environment, with attention to details and a problem-solving mindset.
• Excellent communication skills, including scientific writing, presentations, and project management.
• Collaborative, team-oriented with strong interpersonal skills, to build relationships both internally and externally.
• Commitment to mentoring junior team members and fostering a supportive, learning-focused environment.